http://hdl.handle.net/11055/3 2021-02-23T04:58:54Z 2021-02-23T04:58:54Z Menz, B Wahba, M Slattery, P Thiruvenkatarajan, V Johnson, J http://hdl.handle.net/11055/1080 2021-01-27T05:59:14Z

Title: A Retrospective Study of Topical Lidocaine 5% Plasters in Chronic Off-Label Pain Conditions Authors: Menz, B; Wahba, M; Slattery, P; Thiruvenkatarajan, V; Johnson, J Abstract: Dear Editor, Among many formulations, lidocaine (lignocaine) is available in a transdermal plaster (patch) containing 5% w/w lidocaine (Versatis®, trademark of Grünenthal GmbH used by Seqirus as an authorized user). This formulation is approved for symptomatic treatment of neuropathic pain associated with herpes zoster infection (post-herpetic neuralgia); thus, use of these plasters for other pain conditions is considered off-label. The use of lidocaine 5% plasters (L5%P) in off-label indications has been explored in a limited number of small studies. Currently, L5%P are recommended as a second-line treatment for neuropathic pain in a systematic review by Finnerup et al., limited by weak... Description: Ethics and governance: This project was approved by the Southern Adelaide Local Health Network Human Research Ethics Committee under reference AUD/19/SAC/76 and site-specific assessment reference AR/19/SAC/76

Young, J Macpherson, A Thakerar, A Alexander, M http://hdl.handle.net/11055/1079 2021-01-27T05:55:03Z

Title: Intrathecal Morphine in Postoperative Analgesia for Colorectal Cancer Surgery: A Retrospective Study Authors: Young, J; Macpherson, A; Thakerar, A; Alexander, M Abstract: Background: Colorectal cancer surgery is commonly performed with adequate analgesia essential for patient recovery. This study assessed the effectiveness of intrathecal morphine and patient-controlled analgesia (ITM + PCA) vs patient-controlled analgesia alone (PCA) for postoperative pain management in colorectal cancer surgery. Methods: This retrospective study extracted and analyzed data covering a 4-year period (2014-2018) from a clinical database with 24- and 48-hour postsurgery follow-up. Primary outcomes included pain scores, median opioid consumption (oral morphine equivalence dose), sedation, nausea and vomiting, and length of admission. Outcomes were analyzed for ITM + PCA vs PCA alone, overall and stratified by laparotomy or laparoscopy procedures. Results: In total, 283 patients were included: ITM + PCA (163) and PCA alone (120). Median opioid consumption in the first 24 hours for ITM + PCA vs PCA alone was lower for laparotomy (-32.7 mg, P<0.001) and laparoscopy (-14.3 mg, P<0.001). Median pain score (worst pain) within the first 24 hours for ITM + PCA vs PCA alone was similar for laparotomy (P>0.05) and lower for laparoscopy (-1 unit, P=0.031). Sedation occurred less frequently for ITM + PCA vs PCA at 24 hours (3.5% vs 11.4%, P=0.031), with nonsignificant reduction at 48 hours (4.8% vs 18.8%, P=0.090) for laparotomy, but with no difference for laparoscopy (P>0.05). Incidence of nausea and vomiting and length of admission were similar for ITM + PCA vs PCA alone for laparotomy or laparoscopy (P>0.05). Conclusion: This retrospective study demonstrated that ITM + PCA can achieve similar analgesic effects after laparotomy and laparoscopy colorectal cancer surgery compared with PCA alone while resulting in a reduction of oral opioid consumption and lower incidence of sedation. Keywords: Colorectal; Intrathecal; Morphine; Oncology; Pain; Surgery.

Schug SA Palmer GM Scott DA Alcock MM Halliwell R Mott JF APM:SE Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine http://hdl.handle.net/11055/1071 2020-12-17T10:13:01Z 2020-12-01T00:00:00Z

Title: Acute Pain Management: Scientific Evidence (5th edition) Authors: Schug SA; Palmer GM; Scott DA; Alcock MM; Halliwell R; Mott JF; APM:SE Working Group of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine

2020-12-01T00:00:00Z Loughnan, TE Wake, PB http://hdl.handle.net/11055/1070 2020-12-16T02:55:25Z

Title: Dr Himson Tamur Mulas, the first national specialist anaesthetist in Papua New Guinea Authors: Loughnan, TE; Wake, PB Abstract: Dr Himson Tamur Mulas was born on the Gazelle Peninsula of East New Britain, New Guinea, on 13 March 1934. After finishing his schooling, he was selected to go to Fiji to undertake a medical course at Fiji Central Medical School in 1953, returning to New Guinea in 1958. He successfully completed residency posts and after a period of training in anaesthesia in Port Moresby, was sent to the Alfred Hospital in Melbourne, Australia, in 1966-1967 to further his anaesthetic career. After returning to New Guinea he undertook several administrative posts as well as continuing his anaesthetic career before settling at Nonga Hospital in Rabaul, East New Britain Province. He was first registered as a specialist anaesthetist in 1972. He went on to complete a Diploma in Public Health in New Zealand in 1974, and in 1976 completed a Diploma in Tropical Health and Hygiene at the University of Sydney. He left public hospital anaesthetic practice in 1980. He is recognised as the first New Guinean to be a specialist anaesthetist. He died on 28 July 2000 aged 66 years.