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Please use this identifier to cite or link to this item: http://hdl.handle.net/11055/170
Title: Apnea after Awake Regional and General Anesthesia in Infants: The General Anesthesia Compared to Spinal Anesthesia Study--Comparing Apnea and Neurodevelopmental Outcomes, a Randomized Controlled Trial.
Authors: Davidson, AJ
Morton, Neil S
Arnup, Sarah J
de Graaff, Jurgen C
Disma, Nicola
Withington, Davinia E
Frawley, G
Hunt, Rodney W
Hardy, Pollyanna
Khotcholava, Magda
von Ungern Sternberg, BS
Wilton, Niall
Tuo, Pietro
Salvo, Ida
Ormond, Gillian
Stargatt, Robyn
Locatelli, Bruno Guido
McCann, Mary Ellen
ANZCA/FPM Author: Davidson, AJ
Frawley, G
von Ungern Sternberg, BS
Issue Date: Jul-2015
Citation: Anesthesiology 2015-07; 123(1): 38-54
Abstract: Postoperative apnea is a complication in young infants. Awake regional anesthesia (RA) may reduce the risk; however, the evidence is weak. The General Anesthesia compared to Spinal anesthesia study is a randomized, controlled trial designed to assess the influence of general anesthesia (GA) on neurodevelopment. A secondary aim is to compare rates of apnea after anesthesia. Infants aged 60 weeks or younger, postmenstrual age scheduled for inguinal herniorrhaphy, were randomized to RA or GA. Exclusion criteria included risk factors for adverse neurodevelopmental outcome and infants born less than 26 weeks gestation. The primary outcome of this analysis was any observed apnea up to 12 h postoperatively. Apnea assessment was unblinded. Three hundred sixty-three patients were assigned to RA and 359 to GA. Overall, the incidence of apnea (0 to 12 h) was similar between arms (3% in RA and 4% in GA arms; odds ratio [OR], 0.63; 95% CI, 0.31 to 1.30, P = 0.2133); however, the incidence of early apnea (0 to 30 min) was lower in the RA arm (1 vs. 3%; OR, 0.20; 95% CI, 0.05 to 0.91; P = 0.0367). The incidence of late apnea (30 min to 12 h) was 2% in both RA and GA arms (OR, 1.17; 95% CI, 0.41 to 3.33; P = 0.7688). The strongest predictor of apnea was prematurity (OR, 21.87; 95% CI, 4.38 to 109.24), and 96% of infants with apnea were premature. RA in infants undergoing inguinal herniorrhaphy reduces apnea in the early postoperative period. Cardiorespiratory monitoring should be used for all ex-premature infants.
URI: http://hdl.handle.net/11055/170
DOI: 10.1097/ALN.0000000000000709
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/26001033
Journal Title: Anesthesiology
Type: Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Appears in Collections:Scholarly and Clinical

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