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Please use this identifier to cite or link to this item: http://hdl.handle.net/11055/273
Title: The Role of Perioperative Pharmacological Adjuncts in Cancer Outcomes: Beta-Adrenergic Receptor Antagonists, NSAIDs and Anti-fibrinolytics
Authors: Hiller, JM
Parat, MD
Ben-Eliyahu, S
ANZCA/FPM Author: Hiller, JM
Keywords: cancer
anti-inflammatories
anit-fibrinoytics
Celecoxib
Propranolol
Issue Date: 2015
Citation: 5(3):291-304
Abstract: The perioperative period of cancer surgery and its impact on patients’ long-term cancer outcomes is of increasing research interest. The physiological changes coincident with surgery are characterized by a stress response manifesting as activation of inflammatory pathways and immunosuppression. These changes are potentially deleterious to a patient’s capacity to control residual or released tumor cells. Of particular relevance to anesthesiologists is the role of available adjuncts that may offset these changes to improve patients' recovery from surgery and their long-term cancer outcomes. Animal and human evidence indicates a potential therapeutic benefit for β-adrenergic receptor antagonists, selective cyclooxygenase inhibitors, and anti-fibrinolytics administered through the perioperative period. In addition to reducing the surgical stress response, these agents may effect the cancer-host tissue interface to reduce cancer invasion and dissemination. Future research will focus on defining the role of these agents as integral perioperative adjuncts for cancer surgery.
URI: http://hdl.handle.net/11055/273
DOI: 10.1007/s40140-015-0113-x
Journal Title: Current Anesthesiology Reports
Type: Journal Article
Affiliates: Australian and New Zealand College of Anaesthetists
Appears in Collections:Scholarly and Clinical

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