AIRR - ANZCA Institutional Research Repository
Skip navigation
Please use this identifier to cite or link to this item: http://hdl.handle.net/11055/856
Title: Transition from acute to chronic pain after surgery
Authors: Glare P,
Aubrey K,
Myles PS
ANZCA/FPM Author: ANZCA Clinical Trials Network
Glare, PA
Myles, PS
Issue Date: 13-Apr-2019
Citation: Lancet. 2019 Apr 13;393(10180):1537-1546
Abstract: Over the past decade there has been an increasing reliance on strong opioids to treat acute and chronic pain, which has been associated with a rising epidemic of prescription opioid misuse, abuse, and overdose-related deaths. Deaths from prescription opioids have more than quadrupled in the USA since 1999, and this pattern is now occurring globally. Inappropriate opioid prescribing after surgery, particularly after discharge, is a major cause of this problem. Chronic postsurgical pain, occurring in approximately 10% of patients who have surgery, typically begins as acute postoperative pain that is difficult to control, but soon transitions into a persistent pain condition with neuropathic features that are unresponsive to opioids. Research into how and why this transition occurs has led to a stronger appreciation of opioid-induced hyperalgesia, use of more effective and safer opioid-sparing analgesic regimens, and non-pharmacological interventions for pain management. This Series provides an overview of the epidemiology and societal effect, basic science, and current recommendations for managing persistent postsurgical pain. We discuss the advances in the prevention of this transitional pain state, with the aim to promote safer analgesic regimens to better manage patients with acute and chronic pain.
URI: http://hdl.handle.net/11055/856
DOI: 10.1016/S0140-6736(19)30352-6.
PubMed URL: https://www.ncbi.nlm.nih.gov/pubmed/30983589
Journal Title: Lancet
Type: Journal Article
Study/Trial: Clinical Trial
Appears in Collections:Scholarly and Clinical

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.