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https://hdl.handle.net/11055/1214
Title: | Novel immune biomarkers in complex regional pain syndrome | Authors: | Russo M Georgius P Staats Pires A Heng B Allwright M Guennewig B Santarelli DM Bailey D Fiore TN Tan VX Latini A Guillemin GJ Austin PJ |
Keywords: | complex regional pain syndrome cytokines inflammation kynurenine tetrahydrobiopterin tryptophan |
Issue Date: | 15-Oct-2020 | Source: | Oct 15:347:577330. | Abstract: | We investigated serum levels of 29 cytokines and immune-activated kynurenine and tetrahydrobiopterin pathway metabolites in 15 complex regional pain syndrome (CRPS) subjects and 14 healthy controls. Significant reductions in interleukin-37 and tryptophan were found in CRPS subjects, along with positive correlations between kynurenine/tryptophan ratio and TNF-α levels with kinesiophobia, tetrahydrobiopterin levels with McGill pain score, sRAGE, and xanthurenic acid and neopterin levels with depression, anxiety and stress scores. Using machine learning, we identified a set of binary variables, including IL-37 and GM-CSF, capable of distinguishing controls from established CRPS subjects. These results suggest possible involvement of various inflammatory markers in CRPS pathogenesis. | URI: | https://hdl.handle.net/11055/1214 | ISSN: | 0165-5728 |
Appears in Collections: | Scholarly and Clinical |
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File | Description | Size | Format | |
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Novel Immune Biomarkers in CRPS - Russo2020.pdf Restricted Access | 1.05 MB | Adobe PDF | View/Open Request a copy |
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