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https://hdl.handle.net/11055/1279
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DC Field | Value | Language |
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dc.contributor.author | O’Brien JA | en_US |
dc.contributor.author | McGuire HM | en_US |
dc.contributor.author | Shinko D | en_US |
dc.contributor.author | Fazekas de St Groth B | en_US |
dc.contributor.author | Russo M | en_US |
dc.contributor.author | Bailey D | en_US |
dc.contributor.author | Santarelli DM | en_US |
dc.contributor.author | Wynne K | en_US |
dc.contributor.author | Austin PJ | en_US |
dc.date | 2021-08 | - |
dc.date.accessioned | 2025-01-14T04:35:56Z | - |
dc.date.available | 2025-01-14T04:35:56Z | - |
dc.date.issued | 2021-06-09 | - |
dc.identifier.citation | 15:100283. | en_US |
dc.identifier.issn | 2666-3546 | en_US |
dc.identifier.uri | https://hdl.handle.net/11055/1279 | - |
dc.description.abstract | Diabetic neuropathic pain is a common and devastating complication of type 1 diabetes, but the mechanism by which it develops and persists is yet to be fully elucidated. This study utilised high-dimensional suspension mass cytometry in a pilot cohort to investigate differences in peripheral blood immunophenotypes between type 1 diabetes patients with (n = 9) and without (n = 9) peripheral neuropathic pain. The abundance and activation of several leukocyte subsets were investigated with unsupervised clustering approaches FlowSOM and SPADE, as well as by manual gating. Major findings included a proportional increase in CD4+ central memory T cells and an absolute increase in classical monocytes, non-classical monocytes, and mature natural killer cells in type 1 diabetes patients with pain compared to those without pain. The expression of CD27, CD127, and CD39 was upregulated on select T cell populations, and the phosphorylated form of pro-inflammatory transcription factor MK2 was upregulated across most populations. These results provide evidence that distinct immunological signatures are associated with painful neuropathy in type 1 diabetes patients. Further research may link these changes to mechanisms by which pain in type 1 diabetes is initiated and maintained, paving the way for much needed targeted treatments. | en_US |
dc.subject | CD27 | en_US |
dc.subject | Chronic pain | en_US |
dc.subject | Diabetic neuropathy | en_US |
dc.subject | FlowSOM | en_US |
dc.subject | Immunophenotyping | en_US |
dc.subject | MAPKAPK2 | en_US |
dc.subject | MK2 | en_US |
dc.subject | Mass cytometry | en_US |
dc.subject | SPADE | en_US |
dc.subject | Type 1 diabetes | en_US |
dc.title | T lymphocyte and monocyte subsets are dysregulated in type 1 diabetes patients with peripheral neuropathic pain | en_US |
dc.type | Journal Article | en_US |
dc.type.content | Text | en_US |
dc.identifier.journaltitle | Brain, Behavior, & Immunity – Health | en_US |
dc.identifier.doi | 10.1016/j.bbih.2021.100283 | en_US |
dc.description.affiliates | School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Brain and Mind Centre, 94 Mallett St, Camperdown, NSW, 2050, Australia. | en_US |
dc.description.affiliates | Discipline of Pathology, Faculty of Medicine and Health, The University of Sydney, NSW, Australia. | en_US |
dc.description.affiliates | Ramaciotti Facility for Human Systems Biology, Charles Perkins Centre, The University of Sydney, NSW, Australia. | en_US |
dc.description.affiliates | Sydney Cytometry, The University of Sydney, NSW, Australia. | en_US |
dc.description.affiliates | Genesis Research Services, Broadmeadow, NSW, Australia. | en_US |
dc.description.affiliates | Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. | en_US |
dc.description.affiliates | Department of Diabetes and Endocrinology, John Hunter Hospital, Newcastle, NSW, Australia. | en_US |
dc.description.affiliates | School of Medicine and Public Health, University of Newcastle, NSW, Australia. | en_US |
dc.description.pubmeduri | https://pubmed.ncbi.nlm.nih.gov/34589782/ | en_US |
dc.type.studyortrial | Study | en_US |
dc.type.specialty | Anaesthesia | en_US |
dc.type.specialty | Pain Medicine | en_US |
dc.identifier.fulltextlink | https://www.sciencedirect.com/science/article/pii/S2666354621000867?via%3Dihub | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | restricted | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairetype | Journal Article | - |
Appears in Collections: | Scholarly and Clinical |
Files in This Item:
File | Description | Size | Format | |
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T lymphocyte and monocyte subsets are dysregulated in type 1 diabetes patients with peripheral neuropathic pain.pdf Restricted Access | 2.63 MB | Adobe PDF | View/Open Request a copy |
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